49ers' Ricky Pearsall Ruled Out vs Colts After Knee, Ankle Injury
49ers WR Ricky Pearsall Out for Monday Night Football

The San Francisco 49ers' momentum faces a significant test as they head into a pivotal Monday Night Football showdown. Fresh off a victory that boosted their record to 10-4, the team must now navigate a key offensive absence on the road against the Indianapolis Colts.

Pearsall Sidelined for Crucial Clash

The 49ers have officially ruled wide receiver Ricky Pearsall out for the game against the Colts. This decision comes after Pearsall missed the entire week of practice, nursing knee and ankle injuries sustained during the Week 15 win over the Tennessee Titans.

Head coach Kyle Shanahan confirmed the news on Saturday, stating that the promising receiver got "close, but not close enough" to receiving medical clearance. Due to his inability to participate in any practice sessions, the team opted for a cautious approach. Pearsall will remain in San Francisco to continue his rehabilitation instead of traveling with the squad to Indianapolis.

Timing of the Blow for the 49ers Offense

The absence of Pearsall is particularly stinging given his recent performance. He is coming off his best game of the 2024 season, where he was a standout player in the 37-24 victory over the Titans. In that contest, Pearsall hauled in six passes for a game-high 96 yards from quarterback Brock Purdy.

Through eight games this season, the former first-round draft pick has compiled 31 receptions for 443 yards. His growing connection with Purdy had become a valuable asset for the 49ers' offensive rhythm, making his unavailability a notable setback as the team aims to extend its winning streak and stay alive in the NFC West race.

How the 49ers Plan to Adjust

With Pearsall sidelined, the 49ers' receiving corps will need others to step up. Kendrick Bourne and Demarcus Robinson are expected to see their roles expand significantly within the offensive rotation. The team will rely on its depth when they take the field at Lucas Oil Stadium for the 8:15 p.m. ET kickoff on Monday, December 22.

Adjusting on the fly without one of their most efficient recent targets will be a challenge for Shanahan's play-calling. The game, airing nationally on ESPN and ABC as part of Monday Night Football, will be a true test of the 49ers' resilience and adaptability in the thick of the playoff hunt.